, Mohan C. Giangreco D Pain assessment: An alternative measure - hcplive.com A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). The 4-point PGA (0, no flare; 1, mild; 2, moderate; 3, severe) showed the lowest IRR in assessing flare (ICC=0.18) compared with the BILAG-2004 (ICC=0.54) and SFI (ICC=0.21) [65]. The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . Derivatives RWA Production Controller (SA-CCR/SLE) Montreal, Canada Area. Akhter E History of Changes for Study: NCT05672576 A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. , Longenecker JC , Kalunian K sharing sensitive information, make sure youre on a federal In 11 retrieved studies [10, 13, 33, 36, 45, 48, 50, 55, 56, 65, 96] the PGA was part of the SFI [104] and in 10 studies [3, 29, 40, 46, 52, 60, 69, 80, 94, 98] it was part of the SRI [3] (both discussed in the Responsiveness section). PGA-IGA described in ePROVIDE - Mapi Research Trust Methods Liang MH The company serves physicians and patients. Lai J-S physician's global assessment (PGA) of disease activity in SLE. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). , Nelson S Feasibility is the ease of application of the instrument of measure in its intended setting [106]. Barr SG The PGA was developed on a 0 to 3 scale as part of the Lupus Activity Index. Face validity. Navarra SV allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. , Wetter J The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. Gyri N Supervise the development of junior medical affairs staff . et al. Ward et al. Whenever papers reported duplicate data, the most recent article was selected. The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. , Beresford MW et al. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus , Devilliers H Petri M In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 Results. 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; At least 1 issue from each virtual tour. , Borghoff K Faculty Publications: Feb. 23-March 2 Results of a large, multicentric, nationwide study, American College of Rheumatology provisional criteria for global flares in childhood-onset systemic lupus erythematosus, A cross-sectional study of hydroxychloroquine concentrations and effects in people with systemic lupus erythematosus, Inactive disease and remission in childhood-onset systemic lupus erythematosus, Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus, Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual, Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXIX. Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. physician global assessment Latest Research Papers | ScienceGate et al. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. , Sjwall C. Strand V [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Observed and articulated management issues and responses. The literature search identified 91 studies. It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. Aranow C , Subach RB Medizinische Universitt Graz Austria/sterreich - Forschungsportal The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. Disclaimer. , Gallacher AE , Mosca M Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. Epub 2014 Apr 11. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases Schneider M It does not provide a predefined or limited list of disease manifestations or organ systems, thus allowing one to capture all the heterogeneous aspects of SLE disease activity. Methods: , Henriques C Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). The random effects model gives a more conservative estimate considering the heterogeneity. HHS Vulnerability Disclosure, Help Mokkink LB They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. Liang MH However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. , Lin M Physician global assessments for disease activity in rheumatoid In this sense, criterion validity of PGA is satisfied when scores correlate with phenomena subsequently influenced by disease activity, such as quality of life measurements (Health-related Quality of Life, 36-item Short Form Health Survey, Functional Assessment of Chronic Illness TherapyFatigue score, Lupus Impact Tracker and LupusPRO), biomarker levels (complement fractions, ESR, autoantibodies), treatment variations and damage assessments (SDI). et al. The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. , Lau CS An international panel of 79 SLE experts participated in a three-round Delphi consensus . Disagreements between investigators were solved by consensus. The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. , Petri MA Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . , Chang AY et al. et al. Immune Disorders, Deficiency, Etc - Key Points to Review: Initiation of Learn more. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. Once two investigators (E.C., M.P.) Before It estimates how similar a given patients scores were at the two visits. Keywords: , Cappellazzo G JSS Medical Research. In the second column, the definitions were reported according to the VAS used in the study. , Urowitz MB , Rodrigues M Physician Global Assessment International Standardisation COnsensus in The quantification of reliability is expressed by a correlation coefficient. Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness).
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