Hepatology. Gut. 2012 Apr; 56(4):965-72. 2002 Aug; 36(2):315-25. Alcohol Clin Exp Res. Aliment Pharmacol Ther. 2020; 4(5):561-580. 2006 Apr; 290(4):G583-9. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2000 Mar-Apr; 21(2):135-41. 2000 Jul; 33(1):49-58. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2008 Apr 15; 5(3):338-42. Clin Gastroenterol Hepatol. This graph shows the total number of publications by year. 2011 Jul; 31(6):762-72. 2021 09; 191(9):1564-1579. J Clin Invest. 1991 Oct; 14(4 Pt 1):740-2. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. J Hepatol. 2002 Sep; 132(3):441-9. J Neurol. 2000 Apr 21; 275(16):12207-13. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Hepatology. Liver Int. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 2005 Mar; 39(3):181-8. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. J Trauma. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 1994 Oct 21; 269(42):26396-401. J Biol Chem. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. 1995 Jun; 21(6):303-7. Hepatology. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? J Clin Invest. Aliment Pharmacol Ther. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. 1992 Feb 28; 183(1):184-92. Methods for analyzing c-Jun kinase. Transplantation. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. 1999 Sep 15; 163(6):3474-83. Nucleic Acids Res. J Biol Chem. 2002 May 17; 277(20):18229-37. WebBrenners new job suits his eclecticism. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. The fecal microbiome of ALS patients. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Biol Chem. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. 2008 Feb; 233(2):109-22. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Gastroenterology. Compr Ther. 1996 Feb; 23(2):379-80. Proc Natl Acad Sci U S A. Of Mice and Men and Nonalcoholic Steatohepatitis. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. J Clin Invest. Science. Clin Gastroenterol Hepatol. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Leadership - Institute for Diabetes and Metabolic Health - UC San Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. 2009 Sep; 1(8-9):513-24. 2015 May; 31(3):184-91. Brain. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. 2016; 7:17. Hepatology. Clin Gastroenterol Hepatol. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. J Hepatol. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Exp Biol Med (Maywood). Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. J Clin Invest. Hepatology. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Gut. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. 2012 Nov; 67(11):1357-64. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 2006 Jul; 131(1):272-5. 1987 Sep; 79(3):449-56. Differentiation. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Expression of human immunodeficiency virus-1 in human colonic cells. Human hepatic stellate cell isolation and characterization. J Biol Chem. 2021; 16(12):e0260721. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective This graph shows the total number of publications by year. 2012 Nov; 13(11):1072-82. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2015 Nov; 22(11):1837-45. 1998 Jul; 43(7):1454-64. Hepatology. 2012 Jun 12; 109(24):9448-53. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 2001 Dec; 281(6):G1357-68. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Aliment Pharmacol Ther. Am J Physiol Heart Circ Physiol. Am J Physiol. 2009 Nov; 58(11):1517-27. 2010 Mar; 51(3):1027-36. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. 2007 Apr; 132(4):1434-46. 2018 09; 68(3):1070-1086. Hepatology. Dig Dis. 1998 09; 275(3):G387-92. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Aliment Pharmacol Ther. 2011 Apr; 25(4):1133-44. Hepatol Commun. 1998 10; 275(4):C1058-66. 2017 11; 15(11):1808-1810. 2000 Feb; 31(2):391-8. 2015 Apr 06; 212(4):469-80. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. 2020 05; 72(5):946-959. 1990 Feb; 10(1):75-83. 2014 Jan; 59(1):19-20. 2000 Feb; 88(2):142-9. 2011 May; 53(5):1433-5. 2015 Sep; 39 Suppl 1:S75-9. Introducing PNAS Nexus. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Hepatology. Nat Rev Gastroenterol Hepatol. 1988 Sep-Oct; 8(5):1040-5. DNA Cell Biol. 1984; 49:151-60. Liver Int. J Gastroenterol Hepatol. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 1999 03; 276(3):G591-8. J Clin Gastroenterol. 2006 Jul; 37(7):1691-6. Awareness, treatment, and control of vascular risk factors among stroke survivors. 2003 Feb; 37(2):267-76. We lose people all of the time. 2016 08; 44(3):287-99. 2005 May; 41(5):1085-95. Am J Physiol Gastrointest Liver Physiol. Gastroenterology. 2021 12 09; 12(1):7172. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. J Clin Invest. 1995 Oct; 269(4 Pt 1):G591-9. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. Toll-like receptors and adaptor molecules in liver disease: update. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Signal transduction during liver regeneration. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Proc Natl Acad Sci U S A. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Biochim Biophys Acta. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. J Clin Invest. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Am J Gastroenterol. HBO Special recorded in Las Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. 2007 Nov; 2(4):243-4. USC undermined our ability to do research. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Alzheimer's disease: the vascular connection. Am J Physiol Gastrointest Liver Physiol. Surgery. 2010 Oct; 8(10):891-8, 898.e1-2. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. A molecular defect in human protoporphyria. The enteropathy of prostaglandin deficiency. 2008 Dec; 48(6):2016-26. Adv Second Messenger Phosphoprotein Res. Methods Mol Biol. 2005 Jan; 54(1):134-41. J Immunol. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Am J Physiol. Proc Am Thorac Soc. Nat Med. Neurobiol Aging. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. This graph shows the number and percent of publications by field. Is it the end of the line for the EMT? Blood. 2021 05; 134:105933. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. 2003 Jul 15; 76(1):28-37. 1990 Dec; 283(2):447-57. 1999 Jan 06; 1453(1):161-74. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. Hepatology. 1989 Feb 16; 337(6208):661-3. J Hepatol. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. 2016 Feb 10; 19(2):227-39. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Gastroenterology. 1998 04; 274(4):G669-76. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. 2008 Jun; 118(6):2121-31. J Biol Chem. 2009 Jan 16; 378(3):348-53. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Nat Commun. 1999 Nov; 20(11):2095-100. 1991 12; 54(6 Suppl):1141S-1143S. Gastroenterology. Clinical syndromes of alcoholic liver disease. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Techniques to measure nucleic acid-protein binding and specificity. Infect Immun. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2015 Jul; 22(7):512-8. 2012 Nov; 143(5):1330-1340.e1. 2018 12; 16(12):1974-1982.e7. Neurology. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Carethers will report directly to the chancellor and is part of the leadership team. Am J Physiol. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Best Pract Res Clin Gastroenterol. 2016; 34(5):589-96. Am J Physiol Gastrointest Liver Physiol. J Clin Invest. Gastroenterol Res Pract. To see the data as text. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. 2009 Jan; 49(1):6-8. Yale J Biol Med. 2007 Dec 07; 249(3):518-31. Blood. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Circ Res. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. J Biol Chem. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. 2004 Jan; 2(1):9-13. Biotechniques. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Cell Metab. 2022 09; 609(7925):101-108. 2001 Jul 01; 167(1):173-80. 1991 Mar; 5(3):275-81. J Clin Exp Hepatol. Pharm Res. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. 2009 Apr; 136(4):1423-34. 2017 Feb 01; 312(2):C131-C143. Hepatology. New functions for the aryl hydrocarbon receptor. Front Physiol. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. J Clin Invest. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2004 Aug 15; 78(3):324-32. 1999 Aug; 21(2):238-45. Gastroenterology. Gastroenterology. J Surg Res. Am J Hum Genet. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Molecular epidemiology and cancer prevention. 2020 Apr; 4(4):606-626. Mol Cell Biol. Hepatology. 2011 Jul; 41(7):683-6. 2003 Apr 15; 170(8):4053-60. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. 2017 10 10; 114(41):10808-10809. Am J Physiol Gastrointest Liver Physiol. Hepatology. 2019 Apr 07; 20(7). Clin Gastroenterol Hepatol. 2001 Jan; 33(1):81-90. Cell Metab. Gut. Gastroenterology. Nucleic Acids Symp Ser. Hepatology. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. FASEB J. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 2017 12 12; 8(1):2137. Proc Natl Acad Sci U S A. 2019 07; 70(1):127-141. Comparison of human and bovine protoporphyria. 1979 Sep-Oct; 52(5):449-54. 1999 Jul; 5(4):282-93. Hepatology. Mol Cell Biol. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Moderate alcohol drinking: effects on the heart and liver. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Allergy. 1994 Dec; 124(6):755-60. Hepatology. Proc Natl Acad Sci U S A. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. 2010 Mar; 51(3):942-52. J Clin Invest. Am J Physiol. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. 2003 Nov; 112(9):1383-94. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Ann Hepatol. Aging Ment Health. Mol Cell Biol. Signal transduction during liver regeneration. 2000 Nov 01; 28(21):4306-16. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Hepatology. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. 1989 Aug 15; 49(16):4446-51. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Mol Ther Nucleic Acids. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. 2003 Apr; 37(4):833-41. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. People who share similar concepts with this person. 2006 May; 130(6):1564-72. Gastroenterology. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Nucleic Acids Res. 2005; 23(3-4):264-74. 2001; 160:459-79. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. The enzymatic defect in variegate prophyria. 1997 Nov; 113(5):1589-98. Am J Physiol. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. Hepatology. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Neurology. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. 2020 12 15; 95(24):e3163-e3179. Gastroenterology. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. 2020 02 13; 5(3). Hepatology. 1997 Jan 17; 272(3):1753-60. 2016 05; 139(Pt 5):e28. 1986 Mar; 83(6):1762-6. 2001 Jul 10; 104(2):221-6. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. To see the data as text. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. J Immunol. J Gastroenterol Hepatol. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 2006 Oct; 21 Suppl 3:S84-7. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. 2003 Jul; 39(1):38-46. 2007 Nov; 13(11):1324-32. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 2013 Mar 01; 3(1):4-11. 2007 Aug; 47(2):307-9. 2007 May; 132(5):1937-46. Am J Physiol Gastrointest Liver Physiol. 1999 Aug; 31(4):305-19. Scelzo A, Di Somma S, Antonini P, Montross LP. Semin Liver Dis. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. 2013 Sep 16; 202(6):951-66. Mol Cell Biol. Antioxid Redox Signal. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Am J Pathol. Gastroenterology. J Clin Immunol. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. 2009 Mar 03; 106(9):3300-5. In this role, he leads the School of 1995; (33):212-4. 2015 Nov-Dec; 49 Suppl 1:S25-7. 2011 May; 53(5):1730-41. J Biol Chem. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Gastroenterology. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. 2017 Jun 16; 7:314-323. 2019 01; 49(2):183-193. Ital J Gastroenterol Hepatol. Promising Therapy Candidates for Liver Fibrosis. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. 2011 Jun; 31(3):521-32. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. 1993 Jan; 264(1 Pt 1):G95-103. 2002 Nov; 70(11):6294-301. New Approaches for Studying Alcoholic Liver Disease. Cell Death Differ. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. UCSD Profiles is managed by the UC San Diego 1996 Nov; 271(5 Pt 1):G780-90. Stem Cells Cloning. Gastroenterology. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 1995 Feb; 95(2):803-10. 1990 Jun; 11(6):909-15. J Hepatol. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. J Hum Nutr Diet. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. 1998 May; 27(5):1285-95. 1977 Dec; 60(6):1354-61. 2011 Apr; 25(2):305-17. 1992 Jul-Aug; 11(6):443-52. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Acceptance Post-Bac. Recent advances in liver stem cell therapy. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. 2017 12; 1(10):1043-1057. 2012; 5(Suppl 1):S17. 2014 Dec; 26(12):1802-11. 2003 Mar; 37(3):653-64. 2011 Jan; 53(1):4-6. 1998 Jul 01; 102(1):107-14. 2017 01 03; 127(1):55-64. Therapy for hepatic fibrosis. 1995 Jul; 22(1):241-51. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. J Bone Miner Res. 2019 03; 156(4):1156-1172.e6. 2002 Aug 15; 100(4):1470-7. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. 2000; 32(1 Suppl):32-8. 2009 Jan; 130(1):16-26. Transforming growth factor B and hepatic fibrosis: cause or effect? 2006 Nov; 26(9):1138-47. 2008 Nov; 48(5):1420-9. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Cell Metab. 2010 Jul; 139(1):323-34.e7. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. 2005 Jul 29; 280(30):27879-87. 2001 Nov; 281(5):G1279-89. Mitogens and hepatocyte growth control in vivo and in vitro. 2022 08; 42(3):233-249. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. 2020 01 07; 31(1):189-206.e8. PLoS One. In Vitro Cell Dev Biol. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Neurogastroenterol Motil. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. For c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes does not sensitize these to. 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