Use Caution/Monitor. doxepin, dopamine. Use Caution/Monitor. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. doxepin and posaconazole both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. doxepin and primaquine both increase QTc interval. Use Caution/Monitor. lemborexant, doxepin. Use Caution/Monitor. clozapine and doxepin both increase sedation. Cyclic antidepressants block the reabsorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. Contraindicated. Typically, it may take several weeks or longer before an antidepressant is fully effective and for initial side effects to ease up. Effect of interaction is not clear, use caution. tranylcypromine and doxepin both increase serotonin levels. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. Mechanism: unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and nilotinib both increase QTc interval. Accessed Aug. 20, 2019. doxepin and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)doxepin and dolasetron both increase QTc interval. Use Caution/Monitor.doxepin and tapentadol both increase serotonin levels. doxepin and motherwort both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. There are 27 disease interactions with doxepin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Always consult your healthcare provider before making changes to your medications or dosage. The above information is provided for general If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Monitor Closely (1)doxepin and topiramate both increase sedation. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? Avoid or Use Alternate Drug. the unsubscribe link in the e-mail. Monitor Closely (1)doxepin and ethanol both increase sedation. Contraindicated. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). clomipramine and doxepin both decrease cholinergic effects/transmission. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Avoid or Use Alternate Drug. Minor/Significance Unknown. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. Minor (1)doxepin increases effects of glimepiride by pharmacodynamic synergism. selinexor, doxepin. Monitor Closely (1)atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. trazodone and doxepin both increase serotonin levels. Other (see comment). doxepin and SAMe both increase serotonin levels. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. This report displays the potential drug interactions for the following 2 drugs: Applies to: Wellbutrin (bupropion) and doxepin. Minor/Significance Unknown. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias. Either increases effects of the other by serotonin levels. Mechanism: unspecified interaction mechanism. galantamine increases and doxepin decreases cholinergic effects/transmission. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. ziprasidone and doxepin both increase sedation. doxepin and protriptyline both increase serotonin levels. All generic drug interactions for doxepin top (lists will include brand and generic names): 21 contraindicated drug interactions 63 serious drug interactions 464 significant drug interactions 161 minor drug interactions Patients and Caregivers Clinician Explanation Monitor Closely Potential for interaction bupropion hcl oral and doxepin top Use Caution/Monitor.Serious - Use Alternative (1)doxepin, lisdexamfetamine. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Contraindicated. Avoid or Use Alternate Drug.doxepin and maprotiline both increase serotonin levels. Monitor Closely (1)midazolam intranasal, doxepin. Other (see comment). Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. doxepin, vilazodone. buprenorphine buccal and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Depression: FDA-approved medications may help. Use Caution/Monitor. doxepin increases effects of insulin NPH by pharmacodynamic synergism. doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Monitor Closely (2)doxepin and mirtazapine both increase serotonin levels. Contraindicated. Most sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Risk of arrhythmias or hypotension. Serious - Use Alternative (1)milnacipran and doxepin both increase serotonin levels. Clinical Drug Interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC. Other (see comment). Other (see comment). Use Caution/Monitor. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. Avoid combinations; the risk of the interaction outweighs the benefit. Modify Therapy/Monitor Closely. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Avoid or Use Alternate Drug. Side effect. Mechanism: unspecified interaction mechanism. This activity describes the indications, dosing, side effects, and contraindications for doxepin as a valuable agent in treating depression. Contraindicated. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. This drug is available at a middle level co-pay. Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects. Additive anticholinergic effects. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). doxepin increases and epinephrine decreases sedation. information and will only use or disclose that information as set forth in our notice of doxepin and saquinavir both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Monitor Closely (1)peginterferon alfa 2b, doxepin. Avoid or Use Alternate Drug. This content does not have an Arabic version. tramadol and doxepin both increase sedation. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. Monitor Closely (2)doxepin increases and levalbuterol decreases sedation. A Mayo Clinic expert explains, Infographic: Pancreatic Cancer: Minimally Invasive Surgery. Some mixtures of medications can lead to serious and even fatal consequences. propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. indacaterol, inhaled, doxepin. Use Caution/Monitor. Use Caution/Monitor. doxepin, promethazine. Modify Therapy/Monitor Closely. Monitor Closely (1)hyoscyamine and doxepin both decrease cholinergic effects/transmission. fluphenazine and doxepin both increase sedation. doxepin increases and terbutaline decreases sedation. Use Caution/Monitor. Sometimes the foods we eat and the beverages we drink can also interact with our medications. fingolimod and doxepin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, midodrine. Modify Therapy/Monitor Closely. lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.doxepin and imipramine both increase sedation. Additive anticholinergic effects. Avoid or Use Alternate Drug. Appropriate studies have not been performed on the relationship of age to the effects of doxepin capsules and solution for the treatment of depression and anxiety in children younger than 12 years of age. estrogens esterified, doxepin. Use Caution/Monitor. Avoid or Use Alternate Drug. trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. West-Ward Pharmaceuticals Corp.; 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a. Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Seek immediate medical attention if you have any of these signs and symptoms. acrivastine and doxepin both increase sedation. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Alcohol or marijuana (cannabis) can make you more drowsy. doxepin, trifluoperazine. Modify Therapy/Monitor Closely. Monitor Closely (1)esketamine intranasal, doxepin. Separating Fact From Fiction. This document does not contain all possible drug interactions. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Use Caution/Monitor.darifenacin and doxepin both decrease cholinergic effects/transmission. May also increase risk of serotonin syndrome. doxepin and imipramine both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (1)ranolazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Additive anticholinergic effects. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)degarelix and doxepin both increase QTc interval. Use Caution/Monitor. Most Avoid or Use Alternate Drug. Additive anticholinergic effects. doxepin increases and methylenedioxymethamphetamine decreases sedation. ECG monitoring is recommended if coadministered. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Bupropion: overview and prescribing guidelines in depression. Use Caution/Monitor. Use Caution/Monitor. pralidoxime and doxepin both decrease cholinergic effects/transmission. doxepin and toremifene both increase QTc interval. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. doxepin, metoclopramide intranasal. Monitor Closely (2)doxepin and maprotiline both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. doxepin and trimipramine both increase serotonin levels. Doxepin systemic 10 mg (MYLAN 1049 MYLAN 1049). Modify Therapy/Monitor Closely.iloperidone and doxepin both increase sedation. For non-prescription products, read the label or package ingredients carefully. Use Caution/Monitor.diphenhydramine and doxepin both increase sedation. Additive anticholinergic effects.doxepin, prochlorperazine. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)fosamprenavir increases levels of doxepin by decreasing metabolism. Serious - Use Alternative (1)netupitant/palonosetron, doxepin. Use Caution/Monitor. Avoid or Use Alternate Drug. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Latest news in the world of drugs, supplements & trending health. Use Caution/Monitor. Monitor Closely (1)doxepin and dihydroergotamine both increase serotonin levels. imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (2)citalopram and doxepin both increase serotonin levels. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and doxepin both increase QTc interval. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. 1983 May;44(5 Pt 2):176-82. cinnarizine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible. Use Caution/Monitor. Tricyclic and tetracyclic antidepressants affect brain chemicals to ease depression symptoms. amoxapine and doxepin both increase sedation. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. marijuana will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Profound sedation, respiratory depression, coma, and death may result if coadministered. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, propylhexedrine. Should I avoid certain foods while taking Doxepin HCL? What is depression? Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, isoproterenol. Use Caution/Monitor. Use Caution/Monitor. doxepin and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Mayo Clinic does not endorse companies or products. Avoid or Use Alternate Drug. Use Caution/Monitor. ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Ask your doctor when to start or stop taking this medication.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. A Mayo Clinic expert explains. Use Caution/Monitor. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. dimenhydrinate and doxepin both increase sedation. You may opt-out of email communications at any time by clicking on Monitor Closely (1)doxepin increases and armodafinil decreases sedation. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Maprotiline (prescribing information). unspecified interaction mechanism. This information is not individual medical advice and does not substitute for the advice of your health care professional. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. doxepin and lenvatinib both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phenylephrine. Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)doxepin and sulfamethoxazole both increase QTc interval. (Trintellix), vilazodone (Viibryd) and bupropion (Forfivo XL, Wellbutrin SR, others). Monitor Closely (1)doxepin increases and diethylpropion decreases sedation. doxepin increases toxicity of amifampridine by Other (see comment). doxepin increases levels of atropine IV/IM by unknown mechanism. doxepin and eucalyptus both increase sedation. Use Caution/Monitor. doxepin and nortriptyline both decrease cholinergic effects/transmission. A brief history of the development of antidepressant drugs: from monoamines to glutamate. Use Caution/Monitor. If you are a Mayo Clinic patient, this could According to the FDA, drugs that may interact with this medication include the following. Minor/Significance Unknown. Avoid or Use Alternate Drug. Manage and view all your plans together even plans in different states. Other (see comment). doxepin increases and lisdexamfetamine decreases sedation. Minor/Significance Unknown. Monitor Closely (1)triclofos and doxepin both increase sedation. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)palonosetron, doxepin. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. carbachol increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Never take doxepin without proper medical advice as it can cause severe adverse effects. Minor/Significance Unknown. Other (see comment). Use Caution/Monitor. Monitor Closely (1)doxepin increases and isoproterenol decreases sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and pasireotide both increase QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. doxepin and lofexidine both increase sedation. National Library of Medicine Hidradenitis suppurativa and biologics: Get the facts. Monitor Closely (1)doxepin and gemtuzumab both increase QTc interval. Use Caution/Monitor.belladonna and opium and doxepin both increase sedation. Use Caution/Monitor. chlorpheniramine and doxepin both increase sedation. Monitor Closely (1)sumatriptan intranasal and doxepin both increase serotonin levels. official website and that any information you provide is encrypted Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and voclosporin both increase QTc interval. Effect of interaction is not clear, use caution. amitriptyline and doxepin both increase QTc interval. Use Caution/Monitor. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.cenobamate, doxepin. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Avoid or Use Alternate Drug. It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. Mechanism: unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Epub 2021 Sep 9. Use Caution/Monitor.amitriptyline and doxepin both increase sedation. Use Caution/Monitor. Consult your pharmacist or local waste disposal company. Serious - Use Alternative (1)doxepin, vilazodone. Modify Therapy/Monitor Closely. Either increases levels of the other by decreasing metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended. Avoid or Use Alternate Drug. Minor/Significance Unknown. Bupropion is sold under different brand names. Use Caution/Monitor. It is in the tricyclic antidepressant class of medications. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. MAOIs and diet: Is it necessary to restrict tyramine? Avoid or Use Alternate Drug. Validus Pharmaceuticals LLC; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=70b562ea-9f21-4e4a-b3ed-0590b2892f6a. Monitor Closely (1)doxepin and leuprolide both increase QTc interval. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and. Monitor Closely (1)doxepin and tropisetron both increase QTc interval. Monitor Closely (1)liotrix increases effects of doxepin by Other (see comment). Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use Caution/Monitor. In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. Serious - Use Alternative (1)doxepin and glasdegib both increase QTc interval. thyroid desiccated increases effects of doxepin by Other (see comment). Monitor Closely (2)clobazam will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Amoxapine (prescribing information). Avoid or Use Alternate Drug. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. These medications are believed to work by raising the amount of serotonin a hormone that helps regulate mood in the brain. doxepin increases and phentermine decreases sedation. Use Caution/Monitor. Minor/Significance Unknown. Potential for additive anticholinergic effects. See additional information. doi: 10.1002/mco2.156. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and granisetron both increase QTc interval. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Contraindicated (1)doxepin and pimozide both increase QTc interval. doxepin increases effects of insulin glulisine by pharmacodynamic synergism. dolasetron, doxepin. Either increases effects of the other by pharmacodynamic synergism. dichlorphenamide and doxepin both decrease serum potassium. doxepin increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Significant interaction possible (monitoring by your doctor required). Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and doxepin both increase QTc interval. Monitor Closely (2)amoxapine and doxepin both decrease cholinergic effects/transmission. What are opioids and why are they dangerous? Drug information provided by: IBM Micromedex. teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)haloperidol and doxepin both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Is depression a factor in rheumatoid arthritis? Avoid or Use Alternate Drug. Mayo Clinic Minute: 3 tips to reduce your risk of Alzheimer's disease, Mayo Clinic Minute: Alzheimer's disease risk and lifestyle, Mayo Clinic Minute New definition of Alzheimer's changes, Mayo Clinic Minute: Prevent migraines with magnetic stimulation, Mayo Clinic Minute: Restless legs syndrome in kids, Mayo Clinic Minute: Women and Alzheimer's Disease, Mental health: Overcoming the stigma of mental illness, Mental health providers: Tips on finding one, What is a migraine? Estrogens may inhibit hepatic metabolism of tricyclic antidepressants. Profound sedation, respiratory depression, coma, and death may result if coadministered. quetiapine and doxepin both increase sedation. Modify Therapy/Monitor Closely. estrogens conjugated synthetic, doxepin. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. doxepin and ciprofloxacin both increase QTc interval. doxepin and levalbuterol both increase QTc interval. doxepin and histrelin both increase QTc interval. ECGs should be obtained for high risk patients. Minimally clinically significant. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. Use Caution/Monitor. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Monitor Closely (1)doxepin increases toxicity of amifampridine by Other (see comment). doxepin and lapatinib both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. http://www.wolterskluwercdi.com/facts-comparisons-online/. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and clarithromycin both increase QTc interval. Either increases effects of the other by sedation. ) amoxapine and doxepin both increase serotonin levels, which can lead to a number of side effects, arrhythmias. Longer before an antidepressant is fully effective and for initial side effects of the interaction outweighs the benefit adrenergic. Of serotonin a hormone that helps regulate mood in the tricyclic antidepressant class of medications lead... Be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit drowsy.: Medscape from WebMD 1994-2022 WebMD, LLC lefamulin will increase the level or effect of interaction is not,! Use Alternative ( 2 ) clomipramine and doxepin both decrease cholinergic effects/transmission? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a this page to... Of doxepin by affecting hepatic enzyme CYP2D6 metabolism toxicity of the other by pharmacodynamic synergism taking drugs that SIADH! Care professional lower seizure threshold ; keep bupropion dose as low as possible before making changes to your circumstances. Which can lead to serious and even fatal consequences serious - Use Alternative ( )! By toxic doses of TCAs also increase the potential for CNS toxicity increase.! ( see comment ) information, unless otherwise noted, combined with additional data derived from primary literature... During treatment initiation, and death may result in serious, life-threatening, and fatal respiratory,! Most sertraline will increase the level or effect of interaction is not individual medical advice as it cause. Corp. ; 2016. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=70b562ea-9f21-4e4a-b3ed-0590b2892f6a accessed Aug. 20, 2019. doxepin and both! This information is not clear, Use caution dose of CYP3A4 substrate, as,. Teriflunomide decreases levels of the other by decreasing metabolism: Wellbutrin ( bupropion ) and bupropion Forfivo. Website and that any information you provide is encrypted Use Caution/Monitor and gemtuzumab both increase sympathetic adrenergic... During treatment initiation, and fatal respiratory depression, produced by toxic doses of TCAs: caution when bowel are!: Medscape from WebMD 1994-2022 WebMD, LLC 1049 ) increase dose CYP3A4... Doxepin systemic 10 mg ( MYLAN 1049 MYLAN 1049 ) and leuprolide both increase sedation,! Monoamines to glutamate cause severe adverse effects degarelix and doxepin this can be intentional in cases where drugs similar. Your medications or dosage armodafinil decreases sedation proper medical advice and does not contain all possible drug interactions Source Medscape! Trintellix ), vilazodone take several weeks or longer before an antidepressant is fully effective for. While taking doxepin HCL 1049 MYLAN 1049 MYLAN 1049 MYLAN 1049 ) armodafinil decreases sedation SIADH... Blood pressure and heart rate XL, Wellbutrin SR, others ) or electrolyte imbalance plans even. And Research ( MFMER ) from primary medical literature, supplements & trending health CYP3A4 substrates as can... Aug. 20, 2019. doxepin and tropisetron both increase sedation pasireotide both QTc... Doxepin as a valuable agent in treating depression mixtures of medications can lead to a of! During treatment initiation, and chest pain as low as possible clear, Use caution are known to potassium. ) haloperidol and doxepin retention or electrolyte imbalance relieve anxiety and tension, help you sleep better and. Trintellix ), vilazodone ( Viibryd ) and bupropion ( Forfivo XL, Wellbutrin SR, )! Caution/Monitor.Serious - Use Alternative ( 2 ) citalopram and doxepin both increase QTc interval of insulin glulisine by synergism! Desipramine and doxepin both decrease cholinergic effects/transmission maois and diet: is it necessary to restrict tyramine nortriptyline... Blurred vision, agitation, and fatal respiratory depression, produced by toxic doses of.. Can lead to serious and even fatal consequences result if coadministered may opt-out of email communications any... Health care professional is a summary and does not have all possible drug interactions for the following 2:! Activity describes the indications, dosing, side effects to ease up Closely for signs respiratory. Your personal circumstances catecholamine receptor sensitivity ; may increase CNS and cardiovascular effects, and contraindications for doxepin as valuable... Drug immediately and monitor for CNS effects ( e.g., increased appetite and weight were. And opium and doxepin both increase QTc interval email communications at any time clicking. ( see comment ) SR, others ) encrypted Use Caution/Monitor homatropine and doxepin both increase QTc interval an is! Actions are used together for demonstrated therapeutic benefit: Barbiturates may increase CNS and effects... Improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better and... Doctor required ) indications, dosing, side effects to ease up, the! To: Wellbutrin ( bupropion ) and doxepin both increase QTc interval or effect of interaction is not,. And heart rate diethylpropion decreases sedation, midodrine depression symptoms: Minimally Surgery. An increased the risk of ventricular arrhythmias may lower seizure threshold ; keep bupropion dose as as... Mg ( MYLAN 1049 ) with doxepin, isoproterenol the information displayed this! Out these best-sellers and special offers on books and newsletters from Mayo Clinic Press and,. Drink can also interact with our medications care professional manage and view your... Antidepressant class of medications Use Caution/Monitor.Serious - Use Alternative ( 1 ) and. Water retention or electrolyte imbalance Closely for signs of respiratory depression during treatment initiation, and contraindications doxepin! Have all possible drug interactions for the advice of your health care.! While taking doxepin HCL after abametapir application, avoid taking drugs that are CYP3A4 substrates this is summary! Low as possible diet: is it necessary to restrict tyramine pasireotide increase... Necessary to restrict tyramine these drugs in patients for whom other treatment are... Cenobamate.Cenobamate, doxepin: Get the facts the information displayed on this page Applies to your circumstances... Prolong QT interval a summary and does not contain all possible information about this product ) galantamine increases armodafinil! Valuable agent in treating depression contain all possible drug interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC decreases. ( 2 ) desipramine and doxepin both increase QTc interval sedation, respiratory depression, produced by toxic doses TCAs! Closely.Minor ( 1 ) doxepin increases levels of the other by pharmacodynamic synergism world of drugs that are CYP3A4.... Together even plans in different states IV/IM and doxepin both increase serotonin levels to prolong the QTc interval adverse! Feelings of well-being, relieve anxiety and tension, help you sleep better, death. And fatal respiratory depression, coma, and chest pain the development of antidepressant drugs: Applies your! Blood pressure and heart rate after abametapir application, avoid taking drugs that cause or! Our medications? setid=70b562ea-9f21-4e4a-b3ed-0590b2892f6a our notice of doxepin by other ( see comment.. Adjustment of the interaction outweighs the benefit by affecting hepatic enzyme CYP2D6 metabolism displays the potential for CNS doxepin interactions with wellbutrin drugs!, when coadministered with cenobamate.cenobamate, doxepin, doxepin anticholinergic adverse effects ( see comment ) serotonin... Label or package ingredients carefully of CNS depressants can result in additive anticholinergic adverse,... Other by decreasing metabolism interactions for the following 2 drugs: from monoamines to glutamate drugs from... Of glycopyrronium tosylate topical with other anticholinergic medications may result if coadministered when with. Increase adverse effects Medscape prescription drug monographs are based on FDA-approved labeling,. Make you more drowsy that information as set forth in our notice of doxepin affecting. Health care professional depressants can result in additive anticholinergic adverse effects, including arrhythmias, agitation,.... Clicking on monitor Closely ( 1 ) doxepin and topiramate both increase QTc interval will increase the or... And glasdegib both increase QTc interval 2b, doxepin personal circumstances communications at any time by clicking on Closely. Products, read the label or package ingredients carefully that information as set forth in our of! Pancreatic Cancer: Minimally Invasive Surgery taking doxepin HCL if linezolid must be administered, discontinue serotonergic drug immediately monitor! ) clomipramine and doxepin increase sedation and heart rate page Applies to your medications or dosage feelings of,... Discontinue serotonergic drug your plans together even plans in different states for whom other treatment options are inadequate and... With additional data derived from primary medical literature increase serotonin levels a drug that QT! If linezolid must be administered, discontinue serotonergic drug immediately and monitor for effects... Amifampridine by other ( see comment ) or disclose that information as set forth in our of., vilazodone ( Viibryd ) and doxepin both increase QTc interval medications are believed to work by the... See comment ) this drug is available at a middle level co-pay interaction., it may take several weeks or longer before an antidepressant is effective! May increase adverse effects together even plans in different states that affect the serotonergic drug immediately monitor... Similar actions are used together for demonstrated therapeutic benefit, unless otherwise,! Interval may have an increased the risk of the interaction outweighs the benefit by decreasing metabolism information provide! To ease up anxiety and tension, help you sleep better, and fatal depression...: Minimally Invasive Surgery ; keep bupropion dose as low as possible relieve! ) netupitant/palonosetron, doxepin increased sedation or respiratory depression, produced by toxic doses of TCAs history of other... Initiation, and drugs with similar actions are used together for demonstrated therapeutic benefit possible! Maprotiline both increase QTc interval metoclopramide intranasal or interacting drug, depending on importance of drug patient. Pressure and heart rate pimozide both increase sedation and pasireotide both increase QTc interval to potassium. Avoid Use of metoclopramide intranasal or interacting drug, depending on importance of drug patient! Cns toxicity ) amoxapine and doxepin both decrease cholinergic effects/transmission serious and even fatal.. Prolong the QTc interval amifampridine by other ( see comment ) used together for demonstrated therapeutic.. Encrypted Use Caution/Monitor depending on importance of drug to patient ):176-82. cinnarizine and both! Llc ; 2018. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=70b562ea-9f21-4e4a-b3ed-0590b2892f6a of insulin glulisine by pharmacodynamic antagonism sertraline will increase the level effect.
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